Description
Recombinant insect cell derived rat Factor XII is a single chain glycoprotein purified by ion exchange chromatography. Factor XII is converted, principally from the action of kallikrein, into an active serine protease (Factor α-XIIa) that functions in the in vivo initiation of blood coagulation, fibrinolysis, and kinin formation. The protein purity is determined by SDS-PAGE and activity is determined via complementation in an APTT clotting assay using Factor XII immuno-deficient human plasma. Custom mutants of Factor XII are also available, please contact us for more details